This is Part 4 of the Main Story Walkthrough . Finish Roxxon and the Underground first. Curtain Call should already have turned the plot from two gangs into one person you know.
This chapter covers Breaking Through the Noise, Tinker Tailor Spider Spy, Thicker Than Blood, Like Real Scientists, and The Battle for Harlem.
Breaking Through the Noise
The yellow marker stops being “Roxxon vs Underground” and becomes personal. Play the mission when it appears. Side caches will not spoil less if you delay this; they will just leave you under-levelled for the fights that follow.
Use venom and camouflage the way Part 3 taught — stun clusters, then reset stealth when the floor goes loud. Mega venom is fine here if you have it; do not save every charge for a boss you have not reached yet.
Tinker Tailor Spider Spy
Infiltrate. Do not brawl the whole base on sight. Cameras, patrols, and camouflage still stack. If you trip an alarm, clear a pocket and go invisible again instead of web-zipping into every gun.
This mission is named like a joke. It is not optional flavour. The lab work in the next beats assumes you already know how the Tinkerer operates.
Family, then the device
Thicker Than Blood is Aaron and Miles. Play it when the marker drops. It is not a collectible errand and it is not a good place to pause for photo ops.
Like Real Scientists is the lab, the device, and the plan for Harlem. Listen to the dialogue. The Battle for Harlem assumes you know what they built and why the neighbourhood is the battlefield.
The Battle for Harlem
District-scale fight. This is the last main-campaign beat.
- Stay on the mission objectives. The map will look like a playground of crimes; ignore them until the credits.
- Manage health and venom between waves. The finale is a stamina check as much as a puzzle.
- Watch the ending. Credits, then leftover FNSM jobs, capsules, and photo ops are all that remain on this map.
There is no City That Never Sleeps pack here. When the campaign is done, the next Insomniac story is Marvel’s Spider-Man 2, not another yellow marker on Harlem.
Side content after the credits
Safe to clear after The Battle for Harlem:
- Remaining FNSM app jobs and neighbour requests
- Underground caches and district hideouts
- Time capsules and photo ops
None of those are required for the story ending. Do them for completion, not because the hub still has a yellow path.
What to do next
Hub: Marvel’s Spider-Man: Miles Morales . Previous Insomniac campaign: Marvel’s Spider-Man (2018) .